Stimulation of hepatic glycogenolysis by phorbol 12-myristate 13-acetate
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منابع مشابه
Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate.
Butyrate and the other short-chain fatty acids (SCFAs) are the most abundant anions in the colonic lumen. Also, butyrate is the preferred energy source for colonocytes and has been shown to regulate colonic electrolyte and fluid absorption. Previous studies from our group have demonstrated that the HCO(3)(-)/SCFA(-) anion exchange process is one of the major mechanisms of butyrate transport acr...
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The apical membrane Na(+)/H(+) exchanger isoforms NHE2 and NHE3 are involved in transepithelial Na(+) absorption in the intestine. However, they exhibit differences in their pattern of tissue expression and regulation of their activity by various molecular signals. To study the mechanisms involved in the transcriptional regulation of these genes, we characterized cis-acting elements within the ...
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Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate (PMA, PKC activator) on cardiac fibrosis. So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied. It showed that PMA significantly increased cardiac fibroblasts prolife...
متن کاملThe stimulation of rat astrocytes with phorbol-12-myristate-13-acetate increases the proenkephalin mRNA: involvement of proto-oncogenes.
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied. The proENK mRNA level was elevated at 4 h after the treatment of PMA (2.5 microM) without altering the intracellular proENK ...
متن کاملEffects of phorbol 12-myristate 13-acetate on the differentiation program of embryonic chick skeletal myoblasts.
The effects of phorbol 12-myristate 13-acetate (PMA) on three aspects of myogenesis have been analyzed: (a) fusion of mononucleated myogenic cells to form myotubes; (b) synthesis and accumulation of two muscle-specific proteins; and (c) DNA synthesis. Using autoradiography combined with immunofluorescent localization of muscle-specific light meromyosin and the muscle-specific intermediate filam...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1987
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2410549